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Rev Endocr Metab Disord 15(3):181187 Shan Y, Tan S, Lin Y, Liao S, Zhang B, Chen X et al (2019) The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke

Repeated injections in the same spot can cause lipohypertrophy, which means firm lumps under the skin

Most of the herbal ingredients in these patches (like green tea extract or garcinia cambogia) have very large molecules that are poorly absorbed through the skin

In a phase 2 clinical trial, retatrutide achieved mean adipose tissue reduction of up to 24% over 48 weeks, surpassing existing pharmacological options for obesity treatment (Jastreboff et al., 2023)

This is one of the more stringent rules on our list, especially when combined with the requirement for a 72-hour cancellation notice

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