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NNMT consumes S-adenosylmethionine (SAM) and methylates nicotinamide, depleting cellular methyl pools and downstream NAD+ precursors

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The platform enabled efficient loading of an oligo-PROTAC (DFUS-PS9C), conjugated via click chemistry to an E3 ligase ligand, facilitating targeted ubiquitination and degradation of FUS protein, a strategy with significant implications for PROTAC-based therapies in neurodegenerative diseases

HLA-C*05:01-P2-FV also readily exchanged with dipeptide GL, with loss of KIR2DS1-Fc binding with GL alone, and gain of KIR2DS1 and KIR2DS4 binding after exchange to P2-IA and P2-MW, respectively

Growth hormone release studied for stimulating pulsatile GH secretion via two mechanisms