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The refined TED outcome, which focuses on pathognomonic manifestations, followed the same trend, showing a protective effect at all time points, including a one-year risk of 0.42% in the GLP-1 group compared to 0.53% in the control group (HR 0.79)

Taken together, these effects point to meaningful improvements in arterial health, a critical but often overlooked factor in cardiovascular risk

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Despite a reduction in potency relative to these standards, the observed GIPR activity suggests its potential as a molecular starting point for the rational design of triple-acting ligands (GLP-1R/GIPR/DOR)

Neurology 2003