In individuals without ASCVD, HF, or CKD, choice of therapy should be informed by considerations of weight management (see section 8, Obesity and Weight Management for the Prevention and Treatment of Diabetes), mitigation of metabolic dysfunctionassociated steatotic liver disease (MASLD) or metabolic dysfunctionassociated steatohepatitis (MASH) risk (see section 4, Comprehensive Medical Evaluation and Assessment of Comorbidities), and achievement and maintenance of individualized glycemic goals
Finally, a possible contribution of coronavirus-induced autoantibodies to long COVID has been recently suggested by the demonstration that transfer of IgG from long COVID patients to mice replicates some neurological symptoms, pointing to a causative role of IgG in long COVID pathogenesis (125, 126)
Additional treatments such as muscle preserving agents or intermittent dosing strategies may need to be investigated
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