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One of the more interesting aspects of AOD-9604 is its selectivity

The design of these compounds mainly involves the replacement of the metal ion with rhodium, nickel, or zinc, or may have an inactive ligand attached, such as 4-ethylphenyl

When NNMT is overactive as it tends to be in fat tissue, and increasingly with age and obesity it siphons off the very raw material your cells need to keep NAD+ topped up

Journal of Endocrinology and Metabolism , 3(1-2), 7-15

Comprehensive laboratory monitoring showed no clinically significant changes in vital signs, blood chemistry, or hormonal parameters

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