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Nielsen JS, Mcnagny K M

Endothelial IGF- 1R deficiency disrupts microvascular homeostasis, impairing skeletal muscle perfusion and endurance: implications for age-related sarcopenia

Brown S, Biswas D, Wu J, et al

Research suggests that estradiol deficiency after menopause contributes to an increase in abdominal fat and a decrease in overall metabolic rate

Rebecca Linn from the Division of Anatomic Pathology at CHOP for coordinating the nonBWS liver samples used in this study

However, over longer periods , the changes can be significant think losing fat while gaining or preserving muscle , leading to a leaner, stronger physique