Together, these effects often lead to steady, sustainable weight loss
As monotherapy: When diet and exercise do not provide adequate glycemic control and when metformin is not suitable due to intolerance or contraindications
513,514 In contrast, genetic deletion of 5-LO in P301S tau mice 515 or pharmacologic inhibition of 5-LO with zileuton, 512,516,517 both resulted in significant reduction of tau phosphorylation and glial cell activation and thus ameliorated cognitive deficits
Synergistic neuroprotective therapies with hypothermia
Anti-obesity drug therapy can be offered as an adjunct to a reduced-calorie diet and increased physical activity for weight management in adult patients with an initial body mass index (BMI) of 30 kg/m 2 or 2730 kg/m 2 in the presence of at least one weight-related comorbidity, e.g., dysglycemia, hypertension, dyslipidemia, or obstructive sleep apnea
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