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doi: 10.7759/cureus.10358 249

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HUBERMAN: That's actually the logic of combining different things

Incretins, such as GLP-1 and glucose-dependent insulinotropic polypeptide (GIP), are secreted by entero-endocrine cells of the gastrointestinal tract to stimulate glucose-dependent insulin secretion and beta-cell proliferation

Thus, therapeutic strategies should balance glycemic targets with safety considerations, particularly in patients with reduced renal reserve (140)

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