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They must be esterified into membrane phospholipids and oxidized to transmit ferroptosis signals, a process dependent on acyl-CoA synthetase long-chain family member 4 (ACSL4) and lysophosphatidylcholine acyltransferase 3 [58,59,60]
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Why the combination matters: In the REDEFINE-1 trial, semaglutide alone produced 16.1% weight loss and cagrilintide alone produced 11.8%
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