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In adults with obesity, Tirzepatide produced substantial and sustained reductions in body weight, with nearly two-thirds of participants losing at least 20% of their baseline weight (Jastreboff, New England Journal of Medicine )

Gabriele, S., et al

Semaglutide also slows down the rate at which food leaves your stomach

This can usually explain why, after you reach 30 years, you start noticing more exhaustion, loss in muscle mass, increase in fat retention, and increased emotional distress

"As effective as GLP-1 medications are, many people stop taking them because of cost, side effects or simply not wanting to take a drug long-term," said lead author Shelby Sullivan, MD, director of the Endoscopic Bariatric and Metabolic Program at Dartmouth Health Weight Center and professor of medicine, Dartmouth Geisel School of Medicine

May 2012;37(5):1074-1084