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Starting in the mid-20s, collagen synthesis slows by approximately 1-1.5% per year (2)

Additionally, the prolonged activation of NRF2 has been shown to lead to increased lipid accumulation in the liver due to the upregulation of genes associated with lipid synthesis and storage [206]

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This is what moves the needle, Pierrel adds

Moreover, SUN significantly decreased level of adenosine monophosphate-activated protein kinase (AMPK2), total carnitine, adenosine triphosphate (ATP) and carnitine palmitoyltransferase I (CPT I) expression and significantly increased acetyl-CoA carboxylase-2 (ACC2) expression and malonyl-CoA level in cardiac tissues