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Our study identifies a protein that helps clear excess manganese, which is critical because too much of this metal can damage the brain. Working in collaboration with Yuhan Wang, assistant professor of nutritional sciences, and Aydemir's former graduate student, Jiaqi Zou, who is first author of the study, the team used advanced expansion microscopy to visualize how ZIP14 shifts within cells of the blood-brain barrier in response to excess manganese exposure

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Rapid weight loss has been a hallmark of these medications, which work, in part, by making users feel full earlier by activating receptors of hormones secreted from the intestine (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) to reduce appetite and food intake

References Cigna-a

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Kohen R, Nyska A