When compared to GLP1RAs, which improve insulin sensitivity primarily through weight reduction, a post-doc regression analysis of HOMA2-IR indicates that only 2030% of the improvement in insulin sensitization observed with tirzepatide is due to weight loss (NCT03951753) [77, 78]
And while I dont think animal studies are worthless, theyre preliminary
Your health journey benefits from an approach that addresses multiple wellness aspects simultaneously
These medications mimic the effects of a naturally occurring hormone called GLP-1, which is released in response to food intake
In these cases, a clinician may be able to prescribe an acceptable alternative delivery method prepared by a compounding pharmacy, but these arent recommended by the FDA, so users are advised to be very careful of suspicious websites
For perspective, here is every FDA-approved transdermal patch drug and its molecular weight