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While the laborious hyperinsulinemic-normoglycemic clamp test represents the gold-standard method, insulin resistance can also be measured clinically with the HOMA-IR index from fasting insulin or C-peptide and fasting glucose concentrations, including in people with T2D (unless on insulin treatment) [222, 223, 228]

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Weight loss through any means typically reduces hsCRP, but the magnitude of reduction with GLP-1 based therapies appears to exceed what weight loss alone would predict