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Long term treatment of metformin impedes development of chemoresistance by regulating cancer stem cell differentiation through taurine generation in ovarian cancer cells

(PubMed) Wang Y, Li X, Guo Y, Chan L, Guan X

Benefits (Research Focus) Redox biochemistry research studied for GSH/GSSG cycling kinetics and cellular thiol-disulfide chemistry Glutathione peroxidase / reductase research investigated as substrate for glutathione-utilizing enzymes in enzyme kinetics studies Phase II conjugation research explored for glutathione S-transferase substrate research and xenobiotic conjugation biochemistry Cellular antioxidant pathway research examined for cellular oxidative stress marker research in cell culture systems -Glutamyl peptide chemistry researched for the unique -linkage SAR properties of natural sulfur-containing peptides What Researchers Look At GSH/GSSG ratio measurements and redox state quantification in cell research models Glutathione peroxidase (GPx) and glutathione reductase (GR) enzyme kinetics studies Glutathione S-transferase (GST) substrate specificity and conjugation chemistry research Cellular thiol redox markers and cysteine pool kinetics Comparative biochemistry versus N-acetylcysteine (NAC) and other thiol-containing research compounds Quick Specs Form: Lyophilized white powder Net Peptide Content: 1500 mg per vial Quantity: 1 vial Appearance: White to off-white lyophilizate Reconstitution: Bacteriostatic or sterile water (added by the end researcher) Purity: 99% by HPLC Identity: MS-verified (per COA) Storage: Protect from light Identity Basics Compound: L-Glutathione (reduced form, GSH) Synonyms: GSH

10.1016/j.ctarc.2020.100242 100 GrunwaldT.BockischB.SpillnerE.RingJ.BredehorstR.OllertM

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