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This isn't a minor variable: dietary nicotinamide can saturate NNMT binding sites within 6090 minutes of a meal, reducing the peptide's effective concentration at the target enzyme

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Some enzymes genetically break it down better than others (one of the reasons some handle alcohol than others.) This alcohol breakdown in the liver creates molecules that can lead to the production of reactive oxygen species (ROS) free radicals - tiny, very active molecules that contain oxygen