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Both can be effective in weight loss, but in head-to-head trials, tirzepatide has a slight edge over semaglutide

Screening for diabetic kidney disease Early-stage DKD is usually a silent disease, with minimal clinical manifestations until the patient has progressed to an advanced stage of kidney disease

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The mechanism by which GLP-1 RAs potentially increase suicide or suicide attempts is unclear but may involve an overactivation of the hypothalamic-pituitary-adrenal (HPA) axis [7], rapid weight loss [8], and reduced expression of brain-derived neurotrophic factor which may link weight changes to heightened anxiety and suicidal risk [9]

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