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Some patients benefit from combination T4/T3 therapy, though evidence supporting superiority over levothyroxine monotherapy remains limited and controversial

For patients considering testosterone-plus-semaglutide protocols, genetic insights may help provide context around baseline metabolic flexibility, GLP-1 receptor sensitivity, and appetite-signaling baseline

[24] [25] Adequate sleep : Poor sleep quality and insufficient sleep duration negatively affect metabolic health and may impair incretin responses

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Diabetes & Endocrinology, 10(9), 623633

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