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Elderly patients : Older adults may be more susceptible to side effects and require careful dose titration Concurrent medications : Patients taking insulin or sulfonylureas may require dose adjustments to reduce hypoglycaemia risk The formal contraindication to tirzepatide in the UK is hypersensitivity to the active substance or to any of the excipients

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While compounded versions are not FDA-approved, they follow the same pharmaceutical-grade formulation as brand medications and undergo quality verification

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Chesney, J