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The question is not whether it reaches the brain

Some inherited metabolic disorders (pyridoxine-dependent conditions) may require very large daily doses

From simple fatty liver to nonalcoholic steatohepatitis (NASH) and cirrhosis, its impact is substantial

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Muscle is metabolically active tissue: it is where most of your glucose gets used, so holding onto it supports the blood-sugar benefits many people are on these medications for in the first place