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For example, a small fraction of individuals on Saxenda reported neuropsychiatric issues, such as suicidal thoughts or behaviour, which did not commonly occur with Wegovy

siRNA knockdown Mission esiRNAs targeting human TMEM33 (EHU035611), EGFP (EHUEGFP), murine Tmem33 (Emu078331), murine Fads2 (EMU027741), murine Scd1 (EMU023031) and murine Hsd17b12 (EMU064031) were purchased from Sigma

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These may include treatments such as Mounjaro, Wegovy injections or Wegovy tablets, depending on suitability, availability and clinical assessment