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However, in tauopathies such as AD, as well as in hibernation, tau undergoes hyperphosphorylation catalyzed by various protein kinases, including but not limited to glycogen GSK3, cyclin-dependent kinase 5 (CDK5), and protein kinase A (PKA) [103,104,105], accumulating an excess of 7-10 phosphate groups [106]
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The ratio of oxidized to active glutathione is often used as a way to measure the degree of oxidative stress a cell is experiencing
(Source 4, 5) Initial symptoms of low glutathione may be non-specific and include fatigue, brain fog, sleep disturbance, and low immunity
