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Sentman ML, Brnnstrom T, Westerlund S

The carriers of CYP3A5 rs776746 A allele were overrepresented in the intentionally overdosed group and were more predisposed to acetaminophen-induced hepatotoxicity than individuals with the G allele, that rendered CYP3A5 enzyme inactive due to aberrant gene splicing [100]

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These enzymes are designed to break down proteins into their individual amino acids