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One systematic review and meta-analysis found that, when used alongside standard treatments, these medications can significantly reduce body weight, BMI, and waist circumference

On the flip side, the drugs can cause gastrointestinal problems including diarrhea, constipation, nausea and vomiting

Some studies found systemic vasodilation (with likely consequent reflex tachycardia), while others failed to show this (105107)

Some people with prediabetes, insulin resistance, or certain metabolic disorders may get coverage if their doctor can justify medical necessity, but this is not the norm

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