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Cloning, functional analysis, and mitochondrial localization of Trypanosoma brucei monothiol glutaredoxin-1

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Key enzymes involved in glutathione biosynthesis and recycling were upregulated, including Gclc and Gclm (which form the rate-limiting enzyme glutamate-cysteine ligase), and Gss (glutathione synthetase)

Alcohol use, for example, so taxes Glutathione in the liver that depleted levels are seen in the lungs as well

For individual or dual amino-acid-depleted diets, the specific amino acids were completely removed, and all other amino acids were increased in proportion

Nat Rev Rheumatol 4 , 8289 (2008)