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For exercise performance and VO2 max improvement, the evidence from human exercise studies suggests that MOTS-c's acute rise following high-intensity training is part of the adaptive signal driving mitochondrial biogenesis and cardiovascular remodeling

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The STEP 1 trial's impressive 14.9% weight loss occurred at this maximum dose. Lower doses produced proportionally less weight loss, the relationship appears roughly linear up to 2.4mg

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Ryans scholarly activities include authorship of more than 200 original publications and 45 chapters and reviews, primarily in the field of obesity