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The study found that TPM, when given at a dose of 100 mg/day, is effective in the metrics of a mean reduction in the average monthly migraine frequency, average monthly migraine days, rate of rescue medication, and responder rate compared to the placebo

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Where a plan imposes step therapy, a step therapy exception request should state why the preferred alternative is medically inappropriate rather than simply less desired

The mechanism most safety reasoning is built on is therefore reported as proposed, in papers later retracted which widens the uncertainty around both how Dihexa acts and what its long-term effects might be

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