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It is not a perfectly flat line a daily shot gives a broad peak then a decline but it is more sustained and less pulsatile than natural secretion, and it triggers IGF-1 and somatostatin feedback that dials your own pituitary down while treatment continues

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At the molecular level, the core clock transcriptiontranslation feedback loop is driven by the activators CLOCK and BMAL1, which induce the expression of the repressors PER and CRY1 (ref

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