Catalyzed by the condensation domain C* (CesA_C2), a second L- O -Val-L-Val-D- O -Leu-D-Ala- S -PCP, produced as described above, is then connected to the TE-bound tetradepsipeptide by esterification, thus forming the octadepsipeptidyl- O -TE intermediate ( DP8 ) and, further on, the dodecadepsipeptide- O -TE ( DP12 ) upon extension by a third L- O -Val-L-Val-D- O -Leu-D-Ala unit prior to macrolactonization to the cyclic twelve residue product cereulide (Fig
[2] Klicek, R., Sever, M., Radic, B., & Sikiric, P
Milligrams are a weight measurement of the active peptide
Vandereyken et al., 2023)
Elsayed YY, Khl T, Imhof D
The two rostral burr holes were placed just basal from the posterior interocular line, the two basal burr holes were placed just rostral to the lambdoid suture (and transverse sinuses) on both sides, respectively, and the two middle burr holes were placed in line between the basal and rostral burr holes