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Clinical Evidence The STEP-2 [2] trial included 433 participants over age 65, showing 9.6% weight loss with semaglutide versus 3.4% with placebo

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9:00 - THE EFFECTS AND REPERCUSSIONS OF SYNTHETIC MELATONIN AND TART CHERRY JUICE ON SLEEP QUALITY AND CIRCADIAN RHYTHMS Lindsay Cody Chadron State College Melatonin, a hormone primarily synthesized by the pineal gland, plays a crucial role in regulating circadian rhythms and sleep-wake cycles through its interactions with MT1 and MT2 receptors located in the suprachiasmatic nucleus

doi: 10.1016/j.neubiorev.2020.10.017 50

Most common side effects were gastrointestinal, with 24.5% of participants in the phase 2 obesity trial discontinuing efinopegdutide 10 mg due to AE however when the same dose was used with gradual escalation at the MASLD trial (starting dose 2.4 mg for 4 weeks, then 5 mg for 4 weeks and then 10 mg), only 5.6% of participants discontinued the medication due to AE