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Another concern involves hormonal therapy

If continued consumption outpaces metabolic capacity, causing an increase in BAC levels above 0.31-0.45 percent, life-threatening conditions like alcohol poisoning may occur

Concomitant medicines : Clinicians should review all concurrent medications, particularly insulin or sulfonylureas, given the potential for hypoglycaemia with incretin-based agents

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And as a consequence, markers of tissue inflammation also increase as we age because you're sort of removing this anti-inflammatory compound that's released each night

PMID 24139351