All were double blind, randomized, placebo-controlled trials, and all enrolled middle- or old-aged participants with a previous diagnosis of type 2 diabetes as well as cardiovascular risk factors or cardiovascular disease
This medication is a dual agonist, meaning it mimics two different hormones naturally produced in the gut: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)
While the human relevance has not been established, tirzepatide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2
G., Abenhaim, L., Begaud, B., Zhang, B., & Cooper, C
Thyroid hormone levels did not differ
Nature 615 , 168174 (2023)