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In many cases, the answer is yes

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doi: 10.1111/nmo.12671

Impaired acidification, fusion defects and reduced endosomeautophagosomelysosome pathway flux compromise the clearance of pathogenic aggregates, and raising cellular cAMP or free zinc has been proposed as a strategy to restore lysosomal pH and proteolytic capacity in affected neurons 166

Use an insulated cooler with gel cold packs to maintain a refrigerated temperature (2-8C)