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In the present study (after the 30-day treatment period), Cellgevity significantly increased the activity of rat CYP1A1/2, CYP2C9, and CYP2D6

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With respect to hypertension, several in vivo studies have provided evidence that eNOS uncoupling occurs in animal models of increased blood pressure, including ATII hypertension, 14 DOCA-salt induced hypertension, 57 NOX1 upregulation 83 and genetically determined hypertension 84 in which an uncoupled eNOS was consistently identified as a significant superoxide source

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