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N Engl J Med 380, 347-357 (2019)
Berberine's hydrophilic quaternary ammonium structure significantly impedes passive skin penetration required for transdermal delivery
2017;169:132147.e16
It also summarizes recent advances in therapeutic strategies targeting mitochondria, including pharmacological, genetic, cellular, and material-based approaches, to offer new perspectives and directions for future treatments
Hypoglycemia risk Although the risk of hypoglycemia with these medications is generally low, combining them could potentially increase this risk, especially in patients also taking insulin or sulfonylureas
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