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The April 2026 TGA alert regarding unapproved GLP-1 receptor agonists (including Retatrutide) reinforced the distinction between therapeutic use, which remains unapproved, and research-grade supply for laboratory purposes, which is legally distinct under Australian law

The key principle is that donors must be well and stable on their medication regimen

J Clin Endocrinol Metab 91(9):33443348 Afman LA, Lievers KJA, van der Put NMJ, Trijbels FJM, Blom HJ (2002) Single nucleotide polymorphisms in the transcobalamin gene: relationship with transcobalamin concentrations and risk for neural tube defects

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During this time, enemas, laxatives, and even surgical procedures to shorten the large bowel and speed bowel waste removal were common