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This shift in endpoints reflects a broader reframing of obesity as a chronic disease rather than a lifestyle issue

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By administering the ferroptosis inducers RSL3 and IKE and knocking out the GPX4 gene in immortalized mouse fibroblasts, respectively, Kraft identified a common gene, GCH1, in the surviving cells by genetic sequencing [65]

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Thus, in the well-fed state, insulin enhances the carbon flux through the pentose phosphate pathway, increasing NADPH production Note: insulin also promotes fatty acid synthesis, which depends on a continuous supply of NADPH

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