It is being studied as a triple agonist, meaning it targets GIP, GLP-1, and glucagon receptors
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REDEFINE trials measured outcomes at 68 weeks
showed that focusing NMDA-receptor inhibition specifically on neurons that express the GLP-1 receptor was necessary for this effect, whereas linking MK-801 to other gut peptides that are thought to inhibit feeding was no more effective than MK-801 or the GLP-1 analogue alone at reducing body weight
Hypothesis 4 Body composition Retatrutide's glucagon-receptor activation drives some of its weight loss through increased energy expenditure, which is mechanistically associated with sparing more lean mass than pure-satiety pathways