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However, GPX4 plays the opposite role in follicular B2 cell development, germinal centre response, and antibody response, which is because B1 and marginal zone B cells are more susceptible to lipid peroxidation and ferroptosis than follicular B2 cells [98]

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FOXO4-DRI has three main pharmacogenetic advantages: its stability (resistance to degradation by cellular proteases), half-life (compared to L-peptide equivalents, it's longer), and cell-penetrating properties (cell-penetrating sequences improve intracellular delivery)