A counteracting agent may be the stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, MW 1419, an anti-ulcer peptide per-orally active (12-15) that may also affect many central disturbances (16-23), efficient in inflammatory bowel disease trials (PL 14736) (24, 25) and various wound treatment (26-28), no toxicity reported (12, 13, 24, 25)) which showed various hepatoprotective effects (29-31)
Stohler, H
Several studies have demonstrated that Nrf2 contributes to the anti-inflammatory process as well as increased cysteine production (needed to make glutathione for detoxing)
Given that GCL or GGT pharmacological inhibition or silencing effectively blocks the growth of lymphoid tumor cells in 3D gels, including TIC-like cells, we propose that high glutathione levels in the minority of tumor cells that thrive in 3D gels counteract ROS-induced cell death
Traditional treatments (topical steroids, biologics, immunosuppressants) target these pathways directly
The Practical Maximum: ~53.8 mg/day Calculation: The average adult naturally consumes roughly 1.5 mg of copper daily through a standard diet
