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Phase 2 clinical data showed that, while bioavailability was low following oral administration (~1%), it led to the same efficacy in terms of both glycemic control and weight loss as subcutaneously delivered semaglutide (255)

Consistent with the reductions in BRI, cardiovascular disease risk factors improved in Surmount 1, although sex differences could not be ascertained as male and female observations were pooled in the pivotal publication [2]

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