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Many studies rely on animal models or small human cohorts, which may not fully represent the complexity of human microbiota interactions

John's Wort has the most research behind it for mild to moderate depression, but it interacts dangerously with many medications

It modulates GABA receptors allosterically, influences dopamine and serotonin receptor activity, enhances enkephalin levels, and reduces neuroinflammation, all through a single compound

Saragusty, J., Gacitua, H., King, R

It also inhibited tumor development in other parts of the intestine (6)

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