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Compared with basal insulin and placebo, more frequent gastrointestinal adverse events occurred, including diarrhea, nausea, vomiting, decreased appetite, and constipation in all tirzepatide groups

Researchers who prefer simplicity can use 10mg vials with 1mL reconstitution throughout the first 8-12 weeks (covering doses from 2mg through 8mg within a single draw), then switch to 20mg vials with 1mL reconstitution for the 8mg and 12mg maintenance phases

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Prevention of hypertensive disorders of pregnancyis there a place for metformin