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Given that PS on the cell surface may trigger several reactions, this abnormality may contribute to the erythrocyte pathology commonly encountered in chronic uremia, including ionic transport defects, osmotic alterations, deformations, fragility, and coagulation abnormalities

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By precisely regulating key molecules involved in iron homeostasis and autophagy, such as FPN, heme oxygenase, and NCOA4, it may be possible to improve the specificity and effectiveness of Erastin in EMS treatment, while minimizing excessive inflammation or oxidative damage to surrounding normal tissues

However, the lack of targeted therapies in clinical practice contributes to a poor prognosis for patients with IIRI, which has a high mortality rate of 5069% [6]

Stem Cell Rep