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[1] [2] It belongs to a class of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists , which work by mimicking the action of the naturally occurring hormone GLP-1

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Tirzepatide had finished its last Phase 3 clinical trial SURPASS-5 in February 2022, 50 and it favors activating GIPR (for GIPR, native GIP EC 50 : 0.0334nM, tirzepatide EC 50 : 0.0224nM

37 As a result, patients with these risk factors are often excluded from being prescribed GLP-1RA medications to improve glycemic control

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