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This method avoids "first-pass metabolism." This is a biological process where the concentration of a substance is greatly reduced before it reaches the rest of the body, usually because of the liver or the gut
Nan Fang Yi Ke Da Xue Xue Bao = J South Med Univ 41(12):17631772
It said its experimental drug lepodisiran lowered levels of lipoprotein(a) (Lp(a)) a particle linked to cardiovascular disease by 94% with a single injection
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