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Indeed, treatment with relatively high doses of antioxidants can even be linked to potential adverse effects due to interference with reactive oxygen and nitrogen species involved in normal cellular signaling (Frein et al

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J Biol Chem 254(16):75587560 Gu J, Sun X, Wang G, Li M, Chi M (2011) Icariside II enhances Nrf2 nuclear translocation to upregulate phase II detoxifying enzyme expression coupled with the ERK, Akt and JNK signaling pathways

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