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While room temperature is an option for pens in use, keeping them cool whenever possible is the best way to ensure the medication remains potent

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References: Efficacy and safety of tirzepatide, dual GLP-1/GIP receptor agonists, in the management of type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.2023

62 It is important to mention that the SURPASS-CVOT looking at this effect is still ongoing