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Retatrutide is a first-in-class triple receptor agonist a single molecule that activates the GIP, GLP-1 and glucagon receptors at once

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When G6PD is inhibited in murine cells both in vivo using 6-AN or knockdown, or in vitro using 6-AN or a novel selective small molecule inhibitor of G6PD (G6PDi-1), efferocytosis of apoptotic cells is significantly diminished 107,108,109

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however, acquired multidrug resistance (MDR) has emerged following chronic carboplatin therapy