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Three were randomized, double-blind, placebo-controlled trials, including 16 weeks of dose increases, and one was a double-blind, placebo-controlled, randomized withdrawal trial in which patients assigned semaglutide either continued treatment or switched to a placebo

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[3] Gene expression

Glutathione, being a potent antioxidant, may help mitigate this stress

It helps increase bile acid secretion to help with peristalsis